1. PRECISESADS - Molecular Reclassification to Find Clinically Useful Biomarkers for Systemic Autoimmune Diseases. Mulitcentric European
Consortium supported by IMI (Innovative Medicines Initiative). An international consortium with the aim of a detailed genomic,
epigenomic, transcriptomic, proteomic and metabolomic analysis of a large cohort of patients with various systemic autoimmune diseases to
find common molecular pathways across and independent of established diagnoses.
Consortium director: Marta Alarcon-Riquelme

2. Pyrophosphate as a regulator of calcinosis formation in systemic sclerosis - the investigation of the role of soluble pyrophosphate in
the development of hydroxyapatite crystals in SSc.
Partners: András Váradi, Eszter Kozák - Research Centre for Natural Sciences Budapest,

Vivien Hsu, Rutgers University New Brunswick NJ, USA, John Varga, Northwestern University Chicago IL, USA,

Lorinda Chung, MD, Professor of Medicine (Immunology and Rheumatology) and Dermatology, Stanford
University, Department of Medicine, Division of Immunology and Rheumatology, Stanford CA, USA

Qiaoli Li, PhD, Professor; Thomas Jefferson University Sidney Kimmel Medical College, The PXE
International Center of Excellence in Research and Clinical Care, and Jefferson Institute of Molecular
Medicine, Philadelphia, PA, USA

Naomi Schlesinger, MD, Professor, Vivien Hsu, MD, Professor; Rutgers University, Robert Wood Johnson
Medical School, Department of Medicine, Division of Rheumatology, New Brunswick NJ, USA

Antonia Valenzuela, MD, MS – Department of Clinical Immunology and Rheumatology, Pontificia
Universidad Catolica de Chile

John Varga, MD, Professor, University of Michigan Medical School, Department of Medicine,
Rheumatology Division, Ann Arbor, MI, USA

Formerly:

3. Novel psychodiagnostic tests and inflammatory biomarkers fo the characterisation of cognitive impairment in SLE

4. LYMPHOCYTE ACTIVATION CHARACTERISTICS IN INFLAMMATORY RHEUMATIC DISEASES – CO-OPERATIVE RESEARCH WITH THE 3RD DEPARTMENT OF INTERNAL
MEDICINE, UNIVERSITY OF ERLANGEN-NÜRNBERG – Georg Schett, Louis Munoz, Attila Balog

5. MTHFR-based biomarker in RA and SLE
Partners: Tibor Rauch, Tibor Glant, Rush University Chicago, IL, USA

6. BIOLUPUS Recruitment Project: Clinical Outcomes and Genes. A multicentre European research initiative sponsored by the European
Science Fund. Its aim is the identification of genetic determinants of the development of SLE and the course of the disease.