I. Computer controlled switched mode single electrode extracellular/intracellular (voltage and current clamp mode) amplifier module for recordings with sharp microelectrodes or patch pipettes (two modules):

1. MODES OF OPERATION:

Extracellular voltage measurement

Extracellular single cell stimulation and electroporation (with CURRENT or with VOLTAGE)

Intracellular CURRENT clamp recording

Intracellular VOLTAGE clamp recording

2. HEADSTAGE for ANESTHETIZED HEAD-FIXED PREPARATION:

Input voltage range: ±10 V
Operating voltage: ±15 V
Enclosure: Size: 23 x 70 x 26 mm, grounded
Headstage connector: 8-pole DIN connector
Electrode connector: BNC with driven shield
Ground connector: 2.6 mm banana jack
Reference electrode connector: SMB connector
Input resistance: >10E+13 Ohms (internally adjustable)
Current range: ±120 nA into 100 MOhm

3. MINIATURE HEADSTAGE for FREELY MOVING ANIMALS:

Dimensions: < 24x12x6 (mm)

Weight < 2.5 g

Number of channels: 3 channels for extra/intra and juxtacellular recording and filling; 2  channels for extracellular/LFP recording

Tracking LEDs (red and blue colours)

Acceleration sensor with analog output for X-Y-Z axis

Standard 2.5 m cable

4. ELECTRODE RESISTANCE TEST:

Sensitivity 100 mV/MOhm: application of square current pulses ±1 nA
Display: 3 ½ digit, XXXX MOhms, activated by push-button

5. BANDWIDTH and SPEED OF RESPONSE:

Full power bandwidth (REL = 0): >30 kHz, rise time (10% - 90%)

<10 µs (REL = 100 MOhms)
<5 µs (REL = 5 MOhms) overshoot.

6. INPUTS:
Input impedance analog: 100 kOhms
Input range: ±12 V
Input impedance digital (TTL): 10 kOhms
Input TTL: range: 0-5 V, LO: <0.8 V, HI: >1 V, max. 12 V
Current stimulus input: via BNC connectors, sensitivity 10 nA/V
Step gate input: via BNC connector (TTL)
Gated stimulus: with ten-turn control of holding current,
resolution: 10 pA, range: ±100 nA or with ten-turn control of holding potential,

in VC mode: resolution: 1 mV, range: ±1 V
in VCx10 mode: resolution: 10 mV, range: ±10 V
Polarity: selectable with toggle switch
Voltage command input: via BNC connector, sensitivity /10 mV

7. OUTPUTS:
Output impedance: 50 Ohms
Max. voltage: ±12 V
Current output: BNC connector, sensitivity V/nA
Current output sensitivity: Rotary switch, range: 0.1, 1, 10
Current display: 3 ½ digits, XX.XX nA, resolution 10 pA
Potential output x1: BNC connector, sensitivity 1 mV/mV
Potential output: BNC connector, range: 10, 100, 1000
Potential/Current low-pass filter: 3-pole BESSEL filter, attenuation: -18 dB/octave, corner frequency: 2 kHz
Potential high-pass filter: 1-pole BESSEL filter, attenuation: -6 dB/octave, corner frequencies (Hz): 1, 10, 50, 100, 500

8. BRIDGE BALANCE:
0-100 MOhms (0-1000 MOhms possible): Adjustable with ten-turn control

9. DIGITAL DISPLAYS:
Display mV/MOhms: 3 ½ digits, XXXX mV or XXXX MOhms
Display current: 3 ½ digits, XX.XX nA

10. DIMENSIONS:

Modular, 19” cabinet compatible

II. Computer controlled low pass 8-pole Bessel filter module with gain (two modules)

1. INPUT RANGE: ±12 V

2. INPUT IMPEDANCE:
1 MOhm related to ground input capacitance: 30 pF

3. AC-COUPLING AT INPUT:
Corner frequency of 0.1 Hz

4. OUTPUT IMPEDANCE:
range: ±12 V into 1 kOhm / ±1 V into 50 Ohms

5. GAIN / FREQUENCY MONITOR:
1V / step

6. FILTER:
8-Pole lowpass Bessel filter, attenuation: -48 dB/octave corner frequencies (Hz): 20, 50, 100, 200, 300, 500, 700, 1k, 1,3k, 2k, 3k, 5k, 8k, 10k, 13k, 20k

7. GAIN:
Rotary switch: 1, 2, 5, 10, 20, 50, 100

8. OFFSET-COMPENSATION:
set by ten-turn potentiometer, range ±0.1, ±1 V or OFF, selected by toggle switch 
OFF position separately adjustable with trim pot 

9. DIMENSIONS:
Modular, 19” rackmount cabinet compatible

III. Computer controlled differential amplifier/filter module for small bio-electrical signals (two modules).

1. INPUT RANGE:
±12 V; protected up to ±15 V

2. INPUT IMPEDANCE:
10 MOhms related to ground

3. INPUT CAPACITANCE:
30 pF

4. AC COUPLING AT INPUT:
corner frequency of 0.1 Hz (if AC/0/DC-switch at BNC connector is switched to AC) 

5. OFFSET COMPENSATION:
±0.1 V, ±1 V or ±10 V, set by toggle switch and ten-turn potentiometer

6. HIGHPASS FILTER:
single pole, attenuation: -6 dB/octave, corner frequencies (Hz): OFF, 0.3, 5, 100, 300, 400, 500, 600, 800, 1k, 3k, 10k 

7. LOWPASS FILTER:
single pole, attenuation: -6 dB/octave, corner frequencies (Hz): 30, 100, 300, 500, 700, 1k, 1.3k, 1.5k, 3k, 5k, 10k, 20k

8. GAIN:
rotary-switch: 1-2-5-10-20-50-100

9. GAIN RANGE:
selectable with toggle switch x1, x10, x100

10. OVERLOAD LEDS:
starting to light up at ±10 V 

11. OUTPUT:
impedance 50 Ohms, max ±12 V, short circuit protected

12. DIMENSIONS:

Modular, 19” rackmount cabinet compatible

IV. Computer controlled stimulus isolation module for application of extracellular stimuli e.g. in-vitro, in-vivo freely moving animals

1. INPUT OPERATING MODES:

direct, analog, trigger, TTL trigger selectable with toggle switch

2. FUNCTION MODES:

voltage source, current source selectable with toggle switch

3. SOURCE RANGES:

 ±100 μA, ±1 mA, ±10 mA (current source), range selectable with 3-position rotary switch ±100 V (voltage source)

4. TIME RANGE FACTOR:

 x10 μs, x100 μs, x1 ms selectable with toggle switch, time range up to 99 ms

5. AMPLITUDE POTENTIOMETER:

 3 digits, ±10 V, amplified internally with gain of 10 (voltage source) or scaled with source range switch (current source);polarity selectable with toggle switch

6. TIME POTENTIOMETER:

2 digits, 0 – 99 as multiplication factor selectable

7. INPUT VOLTAGE RANGE:

 ±10 V, amplified internal with gain of 10

8. IMPUT IMPEDANCE: 10 kOhm

9. OUTPUT:

monopolar or bipolar, selected by toggle switch

10. OUTPUT VOLTAGE:

±100 V max., isolated

11. OUTPUT CURRENT:

±10 mA max., isolated

12. DIMENSIONS:

Modular, 19” rackmount cabinet compatible

V. Computer controlled pneumatic drug ejection module.

1. SOURCE GAS:

air, nitrogen, helium etc. no aggressive, combustible or explosive gases, filtered by a 5 μm filter element

2. PRESSURE RANGE:

input pressure: max. 5 bar (1 bar = 105 Pa)

3. PRESSURE CONTROL RANGE:

0-4 bar; display range 0-4 bar or 0-2 bar; display range 0-2.5 bar

4. INPUT AND OUTPUT COUPLINGS:

hose fitting connect type for 4 mm (inner diameter) tubing

5. STATUS / EJECT time indicator:

red/green LED

red light: valve is closed (in EXTERN TIMER, CONT. operation mode); green light: valve is open; Off (no light) valve is closed

6. MODE SELECTION:

four position toggle switch, OFF, EXTERN TIMER, CONT.

7. MINIMUM PRESSURE PULSED WIDTH:

10-20 ms (dependent on tubing), 1 ms with microJECT

8. ANALOG TIMER:

0.001 – 0.1 s, 0.01 - 1 s, 0.1 - 10 s or 1 – 100 s with linear control, range set by rotary switch time base selector (x0.01 s, x0.1 s, x1 s, x10 s)

9. TTL INPUT:

standard BNC connector, TTL (LO = 0-2.5 V, HI = 2.5-12 V), input impedance 10 kW

10. POWER REQUIREMENTS:

115/230 V AC, 60/50 Hz, fuse 2 A / 1 A, slow, 45-60 W (depending on the modules pluggedin)

11. PRESURE TUBING:

outer diameter: 4mm, adaptor for 6 mm outer diameter, tube for connecting pipettes

12. DIMENSIONS:

Modular, 19” rackmount cabinet compatible

VI. Computer controlled timer module

1. PULSE SWITCH:

x 0.01 ms; 5 digits thumb wheel, 0.01 to 999.99 ms, digital

2. DELAY SWITCH:

x 0.01 ms; 5 digits thumb wheel, 0.01 to 999.99 ms, digital

3. CYCLES SWITCH:

3 digits thumb wheel, 1 to 999; 000 = 1000 CYCLES

4. TIMER OUT:

BNC connector, TTL signal

5. TRIGGER OUT:

BNC connector, TTL signal, 1 μs

6. TRIGGER IN:

BNC connector, TTL signal, 10 μs minimum

7. DIMENSIONS:

Modular, 19” rackmount cabinet compatible

VII. Computer controlled 8 channel digital acoustic monitor module.

1. AUDIO MODES:

PITCH / NOISE / THRESHOLD, selected with toggle switch with OFF position

2. INPUT:
BNC connector, impedance 100 kOhms, high-pass filtered in NOISE mode 

3. TRESHOLD:
RANGE and FINE control, ranges: 0.5V, 1V, 2V 

4. VOLTAGE RANGE:
±10 V

5. VOLUME CONTROL:
volume of the internal speaker, one-turn potentiometer 

6. LINE OUT:
3.5 mm stereo jack audio connector, 1 kOhm, 1 V max.

7. DIMENSIONS:

Modular, 19” rackmount cabinet compatible