Encapsulation of poorly water-soluble drug with low dissolution rate and inadequate permeability in a polymer carrier by spray drying can increase its bioavailability. Furthermore, incorporation of drug provides protection against harmful external effects and may ensure controlled drug release. Synthetic, semi-synthetic and natural polymers can be applied for encapsulation of drugs. Micro-or nanpoarticles can also be produced by spray-drying.
The aim of our work is to formulate micro- and nanospheres intended for intranasal application using spray drying methods. Büchi Mini B-290 srpay dryer was applied for preparation of microparticles. Büchi Nano B-90 HP will be used for formulation of nanoparticles. We would like to set the parameters of drying procedures using different polymers (methacrylate copolymer, chitosan and sodium hyaluronate) as encapsulation additives and various acitve ingredients. The physico-chemical properties and the citotxicity of micro- and nanospheres will be investigated. In vitro dissolution and diffusion of products will be determined and compared.

References:

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