During our work a poorly water-soluble meloxicam was milled first time by pulsed laser ablation in liquid, which is a novel possibility to prepare a micro- or nanosized dispersion as an intermediate product/predispersion. The effect of the applied wavelengths (λ = 532 nm), fluence value (energy density 4,5 J/cm2) and polymer type (PVP, PVA, Poloxamer) on the habit, structure, solubility and in vitro properties of the drug were investigated. All of the products were stabile chemically. PLAL has been successfully applied to produce highly stable aqueous suspension containing nanometer-sized meloxicam particles. The average size of the particles produced was between 500-700 nm.

The novelty of the work to present a costeffective procedure, where nano- or microparticles could be prepare in situ/in one step, therefore it should be a basic for the development od drug-device system.

References:

[1] Hopp, B., Nagy, E., Peták, F., Smausz Kolumbán, T., Kopniczky, J., Tápai, C., Budai, J., Papp, I., Kukovecz, A., Ambrus, R. and Szabó-Révész, P., 2018. Production of meloxicam suspension using pulsed laser ablation in liquid (PLAL) technique. Journal of Physics D: Applied Physics. 51, 165401

[2] Gera, Tamás ; Smausz, Tomi ; Kopniczky, Judit ; Galbács, Gábor ; Ambrus, Rita ; Szabó-Révész, Piroska ; Hopp, Béla : Production of ibuprofen in crystalline and amorphous forms by Pulsed Laser Deposition (PLD) APPLIED SURFACE SCIENCE 493 pp. 359-367. , 9 p. (2019)

[3] Hopp, B., Nagy, E., Peták, F., Smausz Kolumbán, T., Kopniczky, J., Tápai, C., Budai, J., Papp, I., Kukovecz, A., Ambrus , R. és Szabó-Révész, P., 2018. Meloxicam szuszpenzió előállítása pulzáló lézeres ablációval folyékony (PLAL) technikával. D Physics D: Alkalmazott fizika. 51, 165401

[4] Gera, Tamás; Smausz, Tomi; Kopniczky Judit; Galbács Gábor; Ambrus, Rita; Szabó-Révész, Piroska; Hopp, Béla: Ibuprofén előállítása kristályos és amorf formában impulzusos lézeres leválasztással (PLD) ALKALMAZOTT FELÜLETUDOMÁNY 493, 359-367. , 9 p. (2019)