Nowadays one of the main aims of pharmaceutical technology is increasing the water solubility of BCS II and BCS IV drugs in the presence of polymer. To achieve that various nanonization techniques have been developed. One of this methods is electrospinning. During electrospinning procedure polymeric fibers with diameters from nano- to micrometers can be made by using electric force. The large surface area, high degree of porosity and amorphous active pharmaceutical ingredient (API) prove the increased water solubility and dissolution rate of the API. The structure and morphology of the electrospun fibers can be varied by using different operating parameters such as method, polymer-API solution, applied voltage, tip-to-collector distance, flow rate and the collector speed. The tested nanofibers were loaded with ciprofloxacin, niflumic acid and loratadine as a model drugs.

The first aim of our study is investigate the effect of the various operating parameters on the nanofibers, therefore the applied procedures could be more efficient, modelable by factorial design. Nanofibers are prepared by using different polymer-API solution, flow rate and also different producing method like conventional needle and needleless electrospinning. After the micrometric and physicochemical properties of the prepared fibers are compared the optimal processing parameters are constructed. Furthermore, in vitro dissolution and penetration of the API are tested. Finally, in vivo experiments are made to get more information about the adaptability of the formulation.

References:

[1] Ambrus, Rita ; Alshweiat, Areen ; Csóka, Ildikó ; Ovari, George ; Esmail, Ammar ; Radacsi, Norbert, 3D-printed electrospinning setup for the preparation of loratadine nanofibers with enhanced physicochemical properties, INTERNATIONAL JOURNAL OF PHARMACEUTICS 567 Paper: 118455 , 8 p. (2019)

[2] Radacsi, Norbert ; Giapis, Konstantinos P. ; Ovari, George ; Szabó-Révész, Piroska ; Ambrus, Rita, Electrospun nanofiber-based niflumic acid capsules with superior physicochemical properties, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 166 pp. 371-378. , 8 p. (2019)