DOCTORAL SCHOOL OF THEORETICAL MEDICINE
Chair: Prof. Gábor Jancsó MD, DSc
Department of Physiology
H–6720 Szeged, Dóm tér 10., Hungary
Phone: (+36 62) 545 099, 544 577, Fax: (+36 62) 545 842
E-mail: jancso@phys.szote.u-szeged.hu
Assistant chair: Prof. Gyula Telegdy MD, MHAS
Institute of Pathophysiology
H–6720 Szeged, Semmelweis u. l., Hungary
Phone.: (+ 36 62) 545 797, Fax : (+ 36 62) 545 710
E-mail: telegdy@patph.szote.u-szeged.hu
Co-operating institutions
Department of Biophysics, Biological Research Center of HAS
Address: H–6726 Szeged, Temesvári krt. 62.
Department of Biochemistry, Biological Research Center of HAS
Address: H–6726 Szeged, Temesvári krt. 62.
Introduction
Two academicians and 23 Doctor of Sciences with significant international collaboration take part in the two training programs: Physiological and Pathological Function of the Neuroendocrine System and Neuroscience. Besides their knowledge and experiences the high scientific requirement guarantees the outstanding level of the PhD thesises. The PhD candidates ought to have a minimum of two original papers, one of them as first author in an international scientific journal with impact factor. Total impact factor required of the publications is 4.0.
Educational Programmes
1. Physiological and Pathological Function of the Neuroendocrine System
Programme director: Prof. Gyula Telegdy MD, MHAS
Institute of Pathophysiology
H–6720 Szeged, Semmelweis u. l., Hungary
Phone.: (+36 62) 545 797, Fax : (+36 62) 545 710
E-mail: telegdy@patph.szote.u-szeged.hu
The programme offers a broad spectrum of training starting from basic sciences through clinical and applied sciences.
The project of synthesis of hormonally active peptides (peptide hormones, neuropeptides) supports the research for basic sciences. The recognition of the structure related to the biological actions synthesis of analogues, agonists and antagonists, may lead not only to the recognition of the biological significance of the peptide, but may offer new therapeutical approaches.
The animal experiments would involve the regulation of secretion and synthesis of hormones – mainly the involvement of the peptides in the central regulation of the endocrine system. The effects of hormones on brain function cover the action on such basic physiological activities as learning, memory, food and water intake, locomotion anxiogenesis-anxiolysis etc. Role of neuropeptides under such pathological activities, as alcohol and narcotics dependence and tolerance.
In the clinical field, a number of biologically active peptides have been revealed with still unclarified, putative physiological roles in the regulation of hypophyseal hormone secretion.
Alcoholism creates a burden to a major proportion of the population. A variety of hormonal dysfunctions are to be expected under acute and chronic alcohol abuse.
Hirstutism, seborrhea and alopecia of women and the diseases of the prostate cause much suffering of a number of patients. Via the study of steroid metabolism in the target organs of androgens, the pathomechanism and new therapeutic methods may be approached.
The gastrointestinal endocrinology would include studying the synthesis, storage, release, transport and neurocrine mode of action of gastrointestinal hormones. The information obtained from these studies enables to understand the physiological and pathological basis of different gastrointestinal disorders and opens new perspectives in the therapy of gastrointestinal disorders.
Research topics
– Molecular background and research of heterogenity of opioid/nociceptin system (Supervisor: A. Borsodi DSc.)
– New therapeutic approaches in acute pancreatitis (Supervisor: L. Czakó PhD)
– Hyperlipidemia induced acute pancreatitis (Supervisor: L. Czakó PhD)
– Early gastrointestinal malignancies: diagnosis and endoscopic therapy (Supervisor: L. Czakó PhD)
– New imaging modalities in the diagnosis of biliopancreatic diseases (Supervisor: L. Czakó PhD)
– The role of cytokines in the pathogenesis of acute necrotizing pancreatitis: experimental and clinical examinations
(Supervisor: Prof. Gy, Farkas DSc.)
– Methodology of neuro-endocrine investigation (Supervisor: Prof. M. Gálfi PhD)
– Functional and molecular characterization of ion transporters in colonic epithelial cells (Supervisor: P. Hegyi PhD.)
– Modern intracellular experimental techniques in gastrointestinal research (Supervisor: P. Hegyi PhD)
– The structure and function of gastrointestinal epithelial cells (Supervisor: Z. Rakonczay jr. PhD)
– The effect of neuropeptides on endocrine, behavioral and autonomic processes (Supervisor: M. Jászberényi PhD)
– Androgen metabolism in peripheral organs (Supervisor: Prof. J. Julesz PhD)
– Effects of environmental harms for the endocrine system (Supervisor: Prof. J. Julesz PhD)
– Manifestations of diabetic autonomic and sensory neuropathy in the digestive tract and the cardiovascular system
(Supervisor: Cs. Lengyel PhD)
– Mechanism of Helicobacter pylori-induced cellular damage in peptic ulcer disease and in ulcer-like dyspepsia
(Supervisor: Prof. J. Lonovics DSc.)
– New therapeutic modalities in the treatment of sphincter of Oddi and gallbladder dysfunction (Supervisor: Prof. J.
Lonovics DSc.)
– Biliary tract motility disorders - Experimental and clinical studies (Supervisor: Prof. J. Lonovics DSc.)
– Role of the colon capsule endoscopy in the early diagnosis of colorectal diseases (Supervisor: László Madácsy PhD)
– New possibilities in the endoscopic practice (simulators and biological models) (Supervisor: László Madácsy PhD)
– Prevention and treatment of post-ERCP pancreatitis in patients at high-risk (Supervisor: László Madácsy PhD)
– Role of endoscopic mucosal resection (EMR) and submucosal dissection (ESD) in the endoscopic management of
early neoplastic lesions of the rectum (Supervisor: László Madácsy PhD)
– Examination of the diagnostic and pathophysiological markers of diabetic gastroparesis (Supervisor: László
Madácsy PhD)
– Examination of early prognostic factors, possibilities and limits of endoscopic management in acute biliary
pancreatitis (Supervisor: László Madácsy PhD)
– Examination of biliary tract hypersensitivity in patients with sphincter of Oddi dyskinesia before and after the
endoscopic management (Supervisor: László Madácsy PhD)
– Diagnosis and management of gallbladder motility disorders (Supervisor: László Madácsy PhD)
– Role of the mediators in the pathogenesis of cardiovascular and neurodegenerative disorders (Supervisor: Zs.
Mezei PhD)
– Problems arising during the care of patients with inflammatory bowel disease (Supervisor: Tamás Molnár PhD)
– Colorectal cancer and polyposis syndromes (Supervisor: Tamás Molnár PhD)
– Correlations between the clinical outcome and therapy in inflammatory bowel disease (Crohn’s disease and
ulcerative colitis) (Supervisor: F. Nagy PhD)
– Vascular differentations in endocrine diseases (Supervisor: A. Nemes PhD)
– Effect of beta-amyloid peptides on the behaviour and learning process (Supervisor: Prof. B. Penke DSc.)
– The role of heavy metal ions in the toxicity of beta-amyloid peptides (Supervisor: Prof. B. Penke DSc.)
– Formation of beta-amyloid oligomers and fibrils (Supervisor: Prof. B. Penke DSc.)
– Effect of neuropeptides on narcotic tolerance and dependence (Supervisor: Prof. Gy. Szabó DSc.)
– Effect of neuropeptides on nociception (Supervisor: Prof. Gy. Szabó DSc.)
– Effect of alcohol tolerance on CNS adaptive processes (Supervisor: Prof. Gy. Szabó DSc.)
– Studies on the pathomechanism of acute pancreatitis (Supervisor: Prof. T. Takács DSc.)
– Role of neurohormones and neuropeptides in the endocrine and neuronal systems (Supervisor: Prof. Gy. Telegdy DSc., MHas)
– Assessment of digestive disorders and cental neuronal afferentation in diabetic autonomic and sensory neuropathy
(Supervisor: T. Várkonyi PhD.)
– The role of intestinal permeability and luminal protease activity in the pathogenesis of functional and inflammatory
bowel diseases (Supervisor: Prof. T. Wittmann PhD)
Main Teaching Courses
– Biostatistics
– Biomedical ethics
– Methodology and ethics of medical publications and presentations
– Computerized methods of research
– Scientific literature
– Detection of hormonal actions on brain function
– Physiology and clinical relevance of gastrointestinal hormones
– Possibility of synthesis of biopolimers
– Pathophysiology of the neuroendocrine system
– Clinical endocrinology
– Molecular genetics in clinical endocrinology
– Molecular neuroendocrinology
– Measurement of gastrointestinal hormones
– Polipeptides, proteins, nucleic acids
– Peptidases and peptide inhibitors
– Morphology of the neuroendocrine system
– Chemistry of natural carbone compounds
– Separation techniques
– Laboratory techniques measuring the function of the endocrine system
– Histology of the neuroendocrine system
2. Neuroscience
Programme director: Prof. Gábor Jancsó MD, DSc
Department of Physiology
H–6720 Szeged, Dóm tér 10., Hungary
Phone: (+36 62) 545 099, 544 577, Fax: (+36 62) 545 842
E-mail: jancso@phys.szote.u-szeged.hu
The Neuroscience Programme of the Medical Faculty of the University of Szeged is dedicated to provide a high quality of educational and research possibilities for young scientists. The program offers a PhD course in Neuroscience to students graduated from medical universities or faculties of natural sciences. It is our hope that the new scientific knowledge considered vital for neuroscientists will allow them to promote our understanding of nervous mechanisms.
We offer high quality educational courses and research possibilities in many areas of neurobiology. The program involves main courses in neuroanatomy, neurophysiology, neuropathophysiology, neurochemistry, neuropharmacology and molecular neurobiology. The main fields of research activities in the frame of this program include morphological, functional, neurochemical and molecular biological investigations concerning visual functions, neurohumoral regulation of sleep, neuronal plasticity, neuronal degeneration and regeneration, pathomechanisms of neurodegenerative diseases, regulation of cerebral circulation, neurobiology of pain and neuronal gene expression. The programme is organised by scientists of international reputation.
Research topics
– Characterization of rhythmic changes in the cutaneous microcirculation in healthy subjects and patients with chronic
diseases (Supervisor: Prof. F. Bari DSc.)
– Characterization of functional and morphological alterations in the cerebral function of rats with hypoperfused brain
(Supervisor: Prof. F. Bari DSc)
– Development of sensory functions. Plasticity in the brain (Supervisor: Prof. Gy. Benedek DSc.)
– Electrophysiological and morphological studies in the sensorimotor systems (Supervisor: Prof. Gy. Benedek DSc)
– G protein-linked neuroreceptors: celullar and molecular research of dimerization (Supervisor: S. Benyhe DSc)
– Opioid and antiopiotic neuropeptides: functional research of endogenic agonists and synthetic analogs (Supervisor: S. Benyhe DSc)
– Characterization of preconditioning mechanisms against hypoxic brain injury (Supervisor: F. Domoki PhD)
– Stress markers in experimental brain hypoxia (Supervisor: F. Domoki PhD)
– Peptidergic mechanisms in the pathophysiology of headaches (Supervisor: M. Dux PhD)
– Neurodegeneration and inflammation (Supervisor: Prof. J. Engelhardt DSc)
– Regulation of neuronal gene expression (Supervisor: Prof. K. Gulya DSc)
– Insulin- and IGF-I-mediated modulation of the functions of primary nociceptive neurons (Supervisor: P. Sántha
PhD)
– The role of endogenous ligands, acting different receptors, on the pain mechanism (Supervisor: Gy. Horváth PhD)
– Investigation of the spinal mechanism of itching (Supervisor: Gy. Horváth PhD)
– Study of the spinal mechanism of pain (Supervisor: Gy. Horváth PhD)
– Plasticity of nocireceptors (Supervisor: Prof. Gábor Jancsó DSc.)
– Morphological and functional plasticity of the pain system (Supervisor: Prof. G. Jancsó DSc)
– Structural and neurochemical plasticity of injured primary sensory neurons (Supervisor: Prof. G. Jancsó DSc)
– Effect of capsaicin on spinal pain mechanisms (Supervisor: Prof. G. Jancsó DSc)
– Molecular biology and pharmacogenetics of psychiatric disorders (Supervisor: Prof. Z. Janka DSc)
– Inhibitory effect of amyloid-beta on axon terminals and GSK-3beta in in vitro tissue culture (Supervisor: J. G. Kiss PhD)
– Neuropathological and neurochemical alterations of the locus coeruleus in Alzheimer's disease (Supervisor: J. G.
Kiss PhD)
– Molecular base of the function of blood-brain barrier (Supervisor: I. Krizbai PhD)
– Pathophysiology and pharmacology of myocardial infarction (Supervisor: Prof. I. Leprán DSc.)
– Repair of the injured cervical cord by embryonic spinal cord grafts (Supervisor: A. Nógrádi PhD)
– Degeneration and regeneration of the CNS pathways: axonal growth-promoting effect of grafted stem cells
(Supervisor: A. Nógrádi PhD)
– The role of integrins in the regeneration of CNS pathways (Supervisor: A. Nógrádi PhD)
– The role of gonadal hormones and neurosteroids in neuroprotection (Supervisor: Prof. Á. Párducz DSc.)
– Gonadal steroids and neuro-glial plasticity (Supervisor: Prof. Á. Párducz DSc.)
– The role of microglia and neuroinflammation in the pathomechanism of Alzheimer' disease (Supervisor: Prof. B.
Penke DSc)
– Protein profile changing in Alzheimer's disease (Supervisor: Prof. Botond Penke DSc)
– Cellular mechanisms of form and shape vision in the primate visual system (Supervisor: Gy. Sáry PhD)
– Immune/inflammatory processes during neuronal degeneration (Supervisor: Prof. L. Siklós DSc)
– Role of calcium in neuronal degeneration (Supervisor: Prof. L. Siklós DSc)
– The use of glutamate scavengers as a possible tool for neuroprotection (Supervisor: Prof. J. Toldi DSc)
– Tryptophan metabolites as possible tools for neuroprotection (Supervisor: Prof. J. Toldi DSc)
Main Teaching Courses
– Biostatistics
– Biomedical ethics
– Methodology and ethics of medical publications and presentations
– Computerized methods of research
– Scientific literature
– The use of scientific databases
– Neuroanatomy and neurohistology
– Neurophysiology
– Neuropathophysiology
– Neuropharmacology
– Neurochemistry
– Neurpathology
– Neuroimmunology
– Molecular neurobiology
Represantive dissertations (title, author, supervisor, year)
Physiological and Pathological Function of the Neuroendocrine System
Representative dissertations (title, author, supervisor, year)
Neuroscience