Szegedi Tudományegyetem - Ahol tudás és szándék találkozik

Chair: Prof. Yvette Mándi MD, DSc

Department of Medical Microbiology and Immunobiology

Faculty of Medicine, University of Szeged

Address: H-6720 Szeged, Dóm Square 10. Hungary

Phone/Fax: +36-62-545-115 / 545-113

E-mail: mandi.yvette@med.u-szeged.hu

 

The School offers a PhD programme to graduate students and focuses its research and training on the role of health threatening microorganisms and dangerous environmental effects. Both epidemiologic and experimental studies are necessary to identify physical and chemical effects that cause health problems. The courses of the Medical Microbiology and Preventive Medicine programs are combined in this Graduate School and offer a wide variety of research.

Microbes in the environment and those living in higher organisms are among the major factors affecting the health and welfare of mankind. Due to chemotherapeutics, antibiotics, and effective vaccination strategies, dreadful infectious diseases have disappeared or considerably lost their significance. However, it has been recognized that their place has not remained unoccupied. The eliminated microbes have been replaced by previously unknown viruses, bacteria or other pathogens. The contribution of bacteria and viruses has been increasingly recog­nized in the pathomechanisms of diseases of unknown aetiology. As a consequence of the extended use of antibiotics, polyresistant strains have been selected. New antigenic mutants have emerged under the pressure of host immune responses. The classical routes of microbial spreading have been replaced by transmission con­nected with hospitalization, drug abuse and occupational hazards. The results of campaigns to eliminate various infections are still dependent on the hygiene, geographical location and standard of living of a given population.

Recent progress in science and application of the results of molecular biology have opened up new prospects in the clarification of the etiology and the path­omechanisms of infectious diseases and in the development of new approaches to the therapy and prevention. The infection by pathogens induces diverse sets of defensive responses from the host immune system. Therefore, in this program we are dealing with the host response, with the innate, and with the adaptive defenses. Cytokines are the major orchestrators of host defense processes and, as such, are involved in respones to exogenous and endogenous insults, repair and restoration of homeostasis. Cytokines however mediate not only host response to invading organisms, tumors, trauma, but they are produced in response to many nonpathogenic stimulants presents in our conventional environment. Consequently, the burgeoning field of cytokine research is unique and interdisciplinary.

We think that our major goal is the training of young professionals who have active and comprehensive knowledge on the structure and function of prokaryotic and eukaryotic cells, molecular organization, physiology and special attributes of mi­crobes. They will be familiar with the different aspects of host-parasite interactions and the mechanisms of host defenses. This and their thorough knowledge in microbial physiology, pathogenicity and chemotherapy will aid them to recognize emerging problems in medical microbiology. The successful training will endow them with the ability to conduct independent research and answer the questions they face during their professional careers.

The research installations include laboratories containing modern equipment (PCR systems, UV microscopes, sterile boxes, CO₂ thermostats, ELISA readers, Gel documentation systems, etc., computers with network connection) and animal quarters. The specialised collections of microbiological and immunological library are found in the Department’s libraries, and the Central Library of the Faculty/University offers the most important medical journals and textbooks.

 

 

Educational programmes

 

A: Medical Microbiology, Antimicrobial Immunity

 

Programme director: Prof. Yvette Mándi MD, DSc

Department of Medical Microbiology and Immunobiology

Faculty of Medicine, University of Szeged

H-6720 Szeged, Dóm Square 10. Hungary

Phone/Fax: +36-62-545-115 / 545-113

mandi.yvette@med.u-szeged.hu

 

 

Research programmes

 

1. Role of Cytokine in Infectious and Non-Microbial Diseases

Coordinator: Prof. Yvette Mándi MD, DSc

Department of Medical Microbiology and Immunobiology

Faculty of Medicine, University of Szeged

H-6720 Szeged, Dóm Square 10. Hungary

Phone/Fax: +36-62-545-115 / 545-113

mandi.yvette@med.u-szeged.hu

 

 

Results in modern immunology shed light on the host-microbe interactions and host defence mechanisms. The cytokine system is involved in almost all the defense mechanisms and reacts to the different infections. Cytokines are messenger molecules that transmit information of importance between cells and have a major impact on growth regulation, cell division, differentiation, inflammation, and immunity. Immune and inflammatory responses can occur anywhere in the body in response to a wide variety of stimuli. The impact of molecular biology on the cytokine field has been revolutionary. They have pleiotropic activities. For this reason, the study of cytokine activation is a must in pathomechanism research. Cytokines are critical for the immunological control of infections. Paradoxically cytokines can be responsible for the development of symptoms of several infectious diseases. In these cases the host responses to a pathogenic organism, rather than the microbe itself may induce injury to host tissues. Prolonged exposure to high concentration of cytokines and other components of the immuno-inflammatory cascade may contribute to the development of multiple organ failure.

The specific aim of the program is to determine the role of cytokine activation in diseases where the activation of the cytokine cascade by microorganisms or other agents or both can be expected. The effects of cytokines on cell growth and differentiation, the molecular mechanism of their interaction, and the roles of gene expression and transcription factors will be studied.

 

Research topics

Study of cytokine gene polymorphism in septic diseases

Supervisor: Yvette Mándi MD, DSc

Cytokine gene polymorphisms

Supervisor: Yvette Mándi MD, DSc

The role of pattern recognition receptors in cytokine induction

Supervisor: Yvette Mándi MD, DSc

The role of cytokines in congenital HCMV infections

Supervisor: Rozália Pusztai MD, PhD

The connection of cytokines and apoptosis in cardiac and haematologic diseases

Supervisor: Klára Megyeri MD, PhD

The connection of cytokines and apoptosis in diseases with complex aetiology

Supervisor: Klára Megyeri MD, PhD

Innate immune reactions is sepsis

Supervisor: Ferenc Somogyvári, PhD

The role of TGF-beta in breast carcinoma

Supervisor: Zsuzsanna Kahán MD, DSc

The role of calcium channels in tumor therapy

Supervisor: Zsuzsanna Kahán MD, DSs

 

2. Molecular Mechanisms in the Development and Prevention of Chronic Infectious Diseases

Coordinator: Dr. Katalin Burian PhD

Department of Medical Microbiology and Immunobiology

Faculty of Medicine, University of Szeged

H-6720 Szeged, Dóm Square 10. Hungary

Phone/Fax: +36-62-545-115 / 545-113

burian.katalin@med.u-szeged.hu

 

 

The subprogramme investigates the pathogen-host relationship at the molecular level, focusing on: 1. characteristics of bacteria and viruses that cause chronic diseases, e.g., cardiovascular diseases such as atherosclerosis and herpes virus infections; 2. immune mechanisms leading to the elimination of bacteria and viruses or to disease of the host; 3. mechanisms and consequences of viral and bacterial latency with reactivations, which often develop following an acute infection; and 4. the relationship between certain intracellular bacterial and viral infections and their potential importance in the pathomechanism of chronic diseases.

Prevention of chronic diseases is a very complex process, involving induction of both humoral and cellular immune responses. Knowledge of the molecular structure and function of structural and non-structural viral and bacterial proteins, and the information about their role in the induction of naturally acquired immune responses, as well as the rapid development of DNA technology, form the bases for the development of efficient and safe preventive measures. Characterization of immune responses induced by individual viral and bacterial proteins as expressed by replication-deficient viral vectors or eukaryotic expression vectors provides information about the functions of these proteins following natural infection as well as the potential use of these proteins as viral or bacterial vaccines.

 

Research topics

Molecular interaction between Chlamydia pneumoniae bacterium and human cytomegalo-virus in vitro in cells of human aortic origin

Supervisor: Katalin Burian MD, PhD

Development of atherosclerosis in mice by infectious agents and the mechanisms involved

Supervisor: Katalin Burian MD, PhD

Molecular mechanism and modulation of genetic (DNA) immunization

Supervisor: Valéria Endrész, PhD

The role of cellular proteins in the molecular mechanisms of infectious diseases

Supervisor: Valéria Endrész, PhD

Immune responses of humans and mice following Chlamydia pneumoniae or cytomegalovirus infections

Supervisor: Katalin Burián MD, PhD

Possibilities of the protection of chlamydial infection

Supervisor: Valéria Endrész, PhD

Innate immunity in pathomechanism of rheumatological diseases

Supervisor: Attila Balogh MD, PhD

 

 

 

3. Pathogenicity of Microorganisms

Coordinator: Klara Megyeri MD, PhD

Department of Medical Microbiology and Immunobiology

Faculty of Medicine, University of Szeged

H-6720 Szeged, Dóm Square 10. Hungary

Phone/Fax: +36-62-546-112 / 545-113

megyeri.klara@med.u-szeged.hu

 

The process of infection can be characterized as a race between the pathogen and the host, with the aim of the pathogen to grow and spread, and the aim of the host to halt the replication and spread of the pathogen. Replication of the pathogen in the host usually results in a disease or death of the host, which leads to the death of the intracellular parasite as well, unless the pathogen has already spread to a new susceptible host. Adaptation of some pathogens to the host establishes a more or less stable and balanced relation, resulting in non-lethal damage to the host and consequent stable existence of the pathogen in the host. Thus, a successful pathogen remains in the host in a "latent" or a "persistent" stage after acute infection, causing as little damage to the host as possible to ensure its continuing presence and periodic replication. An understanding of the complicated relationship involved in the adaptation of the pathogen to the host is crucial in understanding the biology of chronic infections and diseases.

Modern-day microbial genetics has opened new frontiers to study pathogenicity of bacteria and viruses. Molecular cloning has allowed investigators to isolate and modify specific virulence genes and study them with models of infection. However, the exact pathomechanism of some infectious diseases is still unexplored. Many factors determinate the pathogenicity and virulence of microorganisms. Understanding of these factors is necessary to design trully effective and specific antimicrobial strategies. There is a rising number of data about the importance of transactivating protein products of some viruses such as adenoviruses, herpesviruses.

The subprogram also includes investigation of the molecular biology of and the immune responses to recently discovered viruses, such as human herpesvirus 6, that persist in the host throughout life. Although the consequences of latent infection with these viruses are not clear, they might result in development of diseases with yet unknown etiology. Investigation of the viral and host factors in the congenital infections caused by HCMV and HHV-6 is one of the most important topic of this program.

 

Research topics

Viral and host factors in the pathogenesis of prenatal cytomegalovirus infection

Supervisor: Rozália Pusztai MD, PhD

 

The role of apoptosis in the patomechanism of viral infections

Supervisor: Klara Megyeri MD, PhD

 

Virotherapy in malignant diseases

Supervisor: Klara Megyeri MD, PhD

 

The role of Vesicular stomatitis virus in virotherapy

Supervisor: Klara Megyeri MD, PhD

 

Investigation of human pathogenic yeasts and moulds on genetic level for the development of rapid diagnostic methods

Supervisor: Erzsébet Nagy MD, DSc

 

Molecular diagnostic of hepatitis viruses

Supervisor: Judit Deák MD, PhD

 

Epidemiological characteristics of Chlamydia trachomatis infections in different Hungarian populations

Supervisor: Judit Deák MD, PhD

 

Human papilloma virus infections and their correlation with the cytopahtological signs of the cervix

Supervisor: Judit Deák MD, PhD

 

4. Antimicrobial Chemotherapy and Prophylaxis

Coordinator: Prof. József Molnár MD, DSc

Department of Medical Microbiology and Immunobiology

Faculty of Medicine, University of Szeged

H-6720 Szeged, Dóm Square 10. Hungary

Phone/Fax: +36-62-545-114 / 545-113

molnarj@comser.szote.u-szeged.hu

 

We can observe three trends in the development of antimicrobial chemother­apy. First: to isolate new natural, mainly microbial substances. Second: the preparation of synthetic compounds with chemotherapeutic activity or the chemical modification of natural products. Third: alternative interventions not inhibiting bacterial growth directly, but antimicrobial in respect of the final outcome by in­hibit­ing antibiotic resistance mechanisms or adsorbtion of bacteria on the target cells. As concerns immunization against the causative agents of infectious dis­eases, modern vaccines have been developed with the methods of molecular immunology and biotechnology.

The specific aims of the subprogram in the field chemotherapy are the devel­opment of antiplasmid compounds and the elucidation of the mechanisms of action of plasmid eliminating substances, the reverse of multidrug resistance of tumour cells, inhibition of SOS function and prevention of induced mutations in bacteria are also involved in the programme.

Compounds forming complexes with DNA are able to induce changes in the bio­logical activities of bacteria. These mutagenic effects can be prevented by inac­tive derivatives of similar structure or by active derivatives of chemically unrelated compounds.

The antibiotic resistance of some bacteria, bacteriocin, pigment production and nitrogen fixation or tumor induction in plants are coded by plasmids. A part of these plasmids can partly be eliminated by antiplasmid compounds. There are certain correlations between the structure and antiplasmid effect. Using computer programs efficient antiplasmid compounds can be planned and synthesized to inactivate plasmid DNA gyrase and by the modification of CCC form of DNA.

Further aims are related to antibacterial, antitumour and antiviral chemotherapy, i.e. the evaluation of combined chemotherapy with new constituents or combinations which have not been tested so far, e.g. compounds inducing differentiation, apoptosis or modifying the resistance of microbes.

 

Research topics

Resistance, signal transmission in bacterial population

Supervisor: József Molnár MD, DSc

Elimination of plasmids coding for metabolic, antibiotic resistance, hemolysin or nitrogen fixation

Supervisor: József Molnár MD, DSc

Reverse of multidrug resistance in bacteria and tumour cells

Supervisors: József Molnár MD, DSc, Mihály Bak MD, DCS

Occurrence and chemotherapy of multiplex tumors

Supervisor: József Molnár MD, DSc

Interactions between paclitacel and disilaxan resistance modifiers

Supervisor: József Molnár MD, DSc

Disilaxanes as resistance modifiers: in vitro and in vivo effects

Supervisor: József Molnár MD, DSc

Multidrug resistance and clinical resistance studies in testicular-, breast-, head and neck-, and ovary-cancer

Supervisors: Mihály Bak MD, DSc, József Molnár MD, DSc

Antiplasmid and antimicrobial effects of different oils

Supervisors: József Molnár MD, DSc, Judit Hohmann, PhD

 

5. Genomics of Pathogenic Organisms

Coordinator: Prof. Ernő Duda, DSc

Department of Medical Biology

Faculty of Medicine, University of Szeged

H-6720 Szeged, Somogyi Street 4. Hungary

Phone/Fax: +36-62-545-592 / 545-131

E-mail: duda@brc.hu

 

During the last few years we witnessed an explosion of information thanks to different genome projects. Enormous amounts of data have been accumulating on viral and bacterial genes. As we learn the sequence of more and more genes of pathogenic organisms (total genomes of several organisms are already available) we can find more and more targets for rational drug design and development of new antibiotics.

Pathogenic organism carries a number of virulence genes with host origin. Products of these genes interfere with the development of the adequate immune response, inhibit inflammation, induce oncogenic transformation of cells, etc. Within the framework of Genomics of pathogenic organisms we want to explore the genomes of viruses and bacteria to find resistance genes, virulence genes and potential targets of anti-pathogenic drugs and therapies. We also want to study those human (mammalian) genes and sequences, which might be important as sensitivity/resistance factors in cases of certain infectious diseases.

 

Research topics

Virulence genes in pathogens of cellular origin

Supervisor: Ernő Duda, DSc

The genes of immune escape mechanisms in viruses

Supervisor: Ernő Duda, DSc

Cytokine and cytokine receptor genes carried by viruses

Supervisor: Ernő Duda, DSc

The application of recombinant viruses for vaccination

Supervisor: Ernő Duda, DSc

 

 

B: Preventive Medicine

Programme director: Prof. László Nagymajtényi MD, DSc

Public Health Department

Faculty of Medicine, University of Szeged

H-6720 Szeged, Dóm Square 10. Hungary

Phone/Fax: +36-62-545-119 / 545-120

secretary@puhe.szote.u-szeged.hu

 

The etiological role of health damage of environmental origin and adverse features of lifestyle in population diseases is evidenced by results of various international and Hungarian epidemiological studies. Prevention of such effects by reduction or elimination of harmful exposure would greatly contribute to the improvement of the health status of the population in question.

The human exposures originating from the macro- or micro-environment are mostly combined effects of physical and/or chemical factors in various doses.

In the epidemiological studies, the quantitative and qualitative characteristics of the chemical and physical exposures of a given population, and the indicators of their health state (possibly signalising adverse changes) are simultaneously investigated. Factors of the social environment with potential negative impact on health state, must be involved. Based on the results, prevention and intervention programs against negative influences of the natural and/or social environment will be worked out.

Experimental studies are essential in the investigation of ill effects of natural origin. The mechanism of action of harmful physical or chemical factors, or their combinations, can only be achieved by animal experimentation modelling human exposure. In the course of the experimental work, one of the goals may be the elaboration of biomarkers, early indicators of harmful effects with potential application in human toxicology.

The complex investigations outlined above can serve as the basis for risk assessment and management programs, capable of reducing or eliminating harmful effects of environmental chemical or physical factors.

 

Research programmes

 

1. Impact of Social, Economic and Life Style Factors on the Health Status of the Population

Coordinator: Prof. László Nagymajtényi, MD, CSc

Public Health Department

Faculty of Medicine, University of Szeged

H-6720 Szeged, Dóm Square 10. Hungary

Phone/Fax: +36-62-545-119 / 545-120

secretary@puhe.szote.u-szeged.hu

 

Research topics

Health status of the national and ethnic minorities in a region of Hungary

Supervisor: László Nagymajtényi MD, DSc

Impact of the school environment on the health of youth

Supervisor: László Nagymajtényi MD, DSc

The effect of screening of chronic diseases on morbidity and mortality trends

Supervisor: László Nagymajtényi MD, DSc

 

2. Experimental Investigation of Nervous System Damages Caused by Xenobiotics Emitted to the Environment by Human Activity

Coordinator: Prof. László Nagymajtényi MD, DSc

Public Health Department

Faculty of Medicine, University of Szeged

H-6720 Szeged, Dóm Square 10. Hungary

Phone/Fax: +36-62-545-119 / 545-120

secretary@puhe.szote.u-szeged.hu

 

Research topics

Investigation of the functional and behavioural neurotoxic effects of heavy metals and pesticide agents

Supervisor: András Papp PhD

 

Investigation in animal models of functional/behavioural alterations of certain human diseases (e.g. Huntington disease) caused by neurotoxic compounds

Supervisor: Edit Paulik MD, PhD

 

3. Biostatistics

Coordinator: Krisztina Boda PhD

Department of Medical Informatics

Faculty of Medicine, University of Szeged

boda@dmi.u-szeged.hu

 

 

Research topics

 

1. Linear statistical models in epidemiology Krisztina Boda PhD)

2. Clinical epidemiology and biostatistics. (Krisztina Boda PhD)

3. Statistical modelling of sexually transmitted diseases ( Tibor Nyári PhD)

4. Modelling of correlation of pediatric malignant diseases ith infections ( Tibor Nyári PhD)

5.Software application for epidemiologic studies (Karsai János PhD)

 

 

 

RECENT DISSERTATIONS

Multidrug resistance of cancer cells in vitro and its reversal; apoptosis induction by synthetic and plant-derived compounds and HER2 over expression in non-small cell lung cancer patients (Ugocsai Katalin) Dr. Molnár József, 2005

Gene polymorphisms of cytokines and heat shock protein in inflammatory and immune-related diseases (Balog Attila) – Dr. Mándi Yvette, 2005

The role of viral and immunological factors in congenital cytomegalovirus infections (Lukácsi Angéla) – Dr. Pusztai Rozália, 2005

The role of cytokines and apoptosis in in vitro infections and cardiomyopathies (Buzás Krisztina) – Dr. Megyeri Klára, 2005

The strategy of advanced prostate cancer, treatment on the basis on clinical and experimental investigations (Pintér Olivér) – Dr. Molnár József, 2005

Molecular markers of differentiation, resistance, and prognosis in human testicular germ-cell tumors (Mándoky László) – Dr. Molnár József, 2005

Effects of 3-nitropropionic acid on the cortical and peripheral nervous activity in rats (Szabó Andrea) – Dr. Nagymajtényi László, 2005

Experimental investigation of the behavioural toxicity of an environmental pollutant heavy metal, manganese (Vezér Tünde) – Dr. Nagymajtényi László, 2005

Multidrug resistance reversal effect of organosilicon, terpenoid and flavonoid derivatives on various tumor cell lines in vitro (Gyémánt Nóra) – Dr. Molnár József, 2006

Attempts to reduce drug resistance of bacteria and cancer cells (Spengler Gabriella) – Dr. Molnár József, 2006

Investigation of some clinically important toxin-producing anaerobic bacteria and their epidemiology (Terhes Gabriella) – Dr. Nagy Erzsébet, 2006

Interaction between antibiotics and non-conventional antibiotics on resistant bacterial strains (Gunics Gyöngyi) – Dr. Molnár József, 2006

The investigation of cytokine activation and gene polymophisms in Helicobacter pylori infection and in Crohn’s disease (Klausz Gergely) – Dr. Mándi Yvette, 2006

Novel therapeutic modalities for the treatment of ophthalmic diseases (Gallyas Éva) – Dr. Megyeri Klára, 2006

Plasmid curing in ecosystems of bacteria, efflux pump inhibitors in bacteria and cancer cells (Molnár Annamária) – Dr. Molnár József, 2006

Reversal of efflux pump-mediated multidrog resistance in bacteria and tumour cells (Wolfárt Krisztina) – Dr. Molnár József, 2006

Studies of human pathogenic fungi: development of identification schemes, use of molecular genetic methods for their detection and evaluation of their susceptibilities (Dóczi Ilona) – Dr. Nagy Erzsébet, 2006

Health and health determinants among various national minorities in Southeast Hungary - (Kómár Mária) – Dr. Nagymajtényi László, 2006

Studies on the regulation of the Pit2 sodium dependent phosphate transporter amphotropic murine leukemia virus receptor (Jobbágy Zsolt) – Dr. Duda Ernő, 2007

Functional neurotoxicity of insecticide xenobiotics in rats in combined experimental exposure (Lengyel Zsuzsanna) – Dr. Nagymajtényi László, 2007

Studies on the neurobehavioural toxic effects of the mitochondrial toxin, 3‑nitropropionic acid (Lukács Anita) – Dr. Nagymajtényi László, 2007

Vírusok által kódolt chemokin és chemokin receptor gének (Glavinas Hristos) – Dr. Duda Ernő, 2007

Genomics, phosphoproteome and molecular epidemiology analyses of Chlamydia infection (Virók Dezső) – Dr. Gönczöl Éva, 2007

Perspectives in cancer chemotherapy, in vitro and in vivo experiments (Engi Helga) – Dr. Molnár József, 2008

The role of cytokines and pattern-recognition receptors in inflammatory gastrointestinal diseases: clinical and in vitro investigations (Hofner Péter) – Dr. Mándi Yvette, 2008

Significance of genetic instability in development and chemosensitivity of malignant tumors (Olasz Judit) – Dr. Bak Mihály, 2008

Modulation of efflux pumps in tumour cells as a possible way of reversal multidrug resistance (Baráth Zoltán) – Dr. Molnár József, 2008

The biological role of Tribbles proteines in the inflammatory responses of monocytes. The links between inflammation and atherosclerotic signals (Éder Katalin) – Dr. Duda Ernő, 2008

Infections and atherosclerosis: Chlamydia pneumoniae persistence in mice, interaction of chlamydophila pneumoniae and human cytomegalovirus with human dendritic cells (Kis Zoltán) – Dr. Gönczöl Éva, 2008

The influence of socialization to medical profession on the development of family and occupational roles (Molnár Regina) – Dr. Nagymajtényi László, 2009

Neurotoxic effects of manganese oxide nanoparticles in rats (Sárközi Leila) – Dr. Vezér Tünde, 2009

Factors affecting the transplacental transmission of human cytomegalovirus (Kovács Ida Jusztina) – Dr. Pusztai Rozália, 2009

From Hippocratic oath to patient safety culture (Bognár Ágnes) – Dr. Nagymajtényi László, 2009

The effect of regular physical activity on health and health behaviour( Bóka Ferenc) Paulik Edit 2010

The role of alarmins - human defensins and HMGB1 - in gastrointestinal diseases (Katalin Ágnes Kocsis) Mándi Yvette 2010

RNA metabolism in mycobacteria: The role of RNase E(Csanádi Ágnes) Miczák András 2010

Generation and evaluation of vaccine candidates against Mycobacteria (Faludi Ildikó) Endrész Valéria 2010

Evaulatory methods in diagnosis and control of tubercolosis Ködmön Csaba Nagy Erzsébet2010

The effects of Herpes simplex virus and Vesicular stomatitis virus infections on the expression patterns of p63 and Bax in epithelial cell lines (Orosz László) Megyeri Klára 2010

Combat resistance in prokaryotic and eukaryotic cells (Schelcz Zsuzsanna) Molnár József 2010

Neurotoxicity of a modelled complex environmental heavy metal exposure in rats (Kőrösiné Horváth Edina) Papp András 2011

Nervous system effects and oxidative stress in rats treated with metal oxide nanoparticles (Oszlánczi Gábor) Vezér Tünde 2011

Early detection and treatment of certain malignant tumors (Horváth Zsolt )Bak Mihály 2011

Genetic polymorphisms of RAGE, NOD1 and beta-defensins in multiple sclerosis, stroke and pancreatitis (Tiszlavicz Zoltán) Mándi Yvette 2011

Comparative molecular genetic studies of nucleic acid detection of human noroviruses (Kele Beatrix) Deák Judit 2011.

New possibilities for the tailored therapy of breast cancer patients (Nikolényi Alíz) Kahán Zsuzsanna 2011

Results of a local antibiotic management program and national survey on antimicrobial consumption and on the availability of microbiology laboratory services on adult intensive care units in Hungary(Pethő Zsolt) Nagy Erzsébet 2011

Health, health-related behavior and Quality of Life of middle- and old-aged women in Hungary (Marót Nagy Ágnes) Paulik Edit 2012

New approaches for the prevention of radiation lung damage in breast cancer (Varga Zoltán) Kahán Zsuzsanna 2012

Individualized treatment of early breast cancer (Kelemen Gyöngyi) Kahán Zsuzsanna 2012

Methodological approaches to evidence based guidelines in burn injury (Kiss Erika)Horváth Andrea Rita 2012.

Inhibition of drug resistance (Serly Julianna) Molnár József 2012

Central nervous effect of manganase in rats investigated by repeated simultaneous electrophysiological and behavioral recording (Takács Szabolcs) Papp András 2012

Iron oxide nanoparticles and their toxicological effects: in vivo and in vitro studies (Szalai Brigitta) Vezér Tünde 2012

The complexities of health status and its influencing factors among people living along the Hungarian-Romanian (Nédó Erika) Paulik Edit 2012.