Innovative research areas in our Institute

The research laboratory of the Psychiatric Clinical Institute is involved in high quality work in the fields of neurodegenerative diseases and psychiatric disorders, in preclinical and clinical phase.

Research areas:

1. Finding biomarkers in neurodegenerative and psychiatric disorders detected from teardrops (lacrima), liquor, blood serum, human fibroblasts and transgenic stress model mouse strains in proteomic and transcriptional levels;
2. The effects of acute depression on Alzheimer's disease related molecular proccesses in APP/PSEN transgenic and wild type mice;
3. The impcats of APO B transgene on Alzheimer's disease associated molecular changes in stress triggered depression model in mice;
4. Expression of AdipoR1 and AdipoR2 in the cortical and hippocampal areas of a wild type and an Alzheimer's disease model mouse strain and the effects of restrain stress exposure
5. Alzheimer's disease specific lipimic analysis of cerebrospinal fluid;
6. The SNP analysis of TREM and defensins and the proteomic measurement of their alterations in CSF and serum of patients with Alzheimer's disease;
7. Metanalysis of different peripherial markers of patients with Alzheimer's disease and majro depression;
8. Researching the possible role of TREM-1 protein in the development of Alzheimer's disease;
9. Phenotyping of thetransgenicmouse model for ADHD;
10. Genetic analysis of the RELN gene: Gender specific association with Alzheimer's disease;
11. Investigating protective compounds against stress caused by circadian rhythm disturbances, using a bdelloid rotifer as an optimal in vivo aging model.
12. Relation and contradiction between extended lifespan and amyloid beta metabolism under complete dietary restriction, using a bdelloid rotifer as an optimal aging model.

Our team members:

Prof. János Kálmán, full professor, head of the institute

Magdolna Pákáski, PhD, MD, associate professor, deputy head of research

Zsolt Datki, PhD, associate professor, head of research laboratory

Zita Oláh, assistant professor

Ilona Hatvani, laboratory assistant

Evelin Balázs, PhD student